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Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate

CAT:
37-BNC402136-500
Size:
500 µL
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate - image 1
Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate - image 2
Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate - image 3
Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate - image 4
Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate - image 5
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Anti-OCT-2 (POU2F2) (B-Cell Marker) (OCT2/2136), CF640R conjugate

  • Description: Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Synonyms: Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Oct-2; Octamer-binding protein 2; Octamer-binding transcription factor 2; OTF-2; POU domain class 2 transcription factor 2; POU2F2
  • CAS Number: 9007-83-4
  • UNSPSC: 41116161
  • UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
  • Gene Name: POU2F2
  • Gene ID: 5452
  • NCBI Gene ID: 147381
  • UniProt: P09086
  • Cellular Locus: Nucleus
  • Host: Mouse
  • Species Reactivity: Human
  • Immunogen: Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary)
  • Target Antigen: 44836
  • Clonality: Monoclonal
  • Isotype: IgG1 κ
  • Clone: OCT2/2136
  • Conjugation: CF640R
  • Source: Animal
  • Applications: IHC, FFPE (verified)
  • Validated Applications: IHC, FFPE
  • Field of Research: Immunology, Transcription factors
  • Positive Control: Raji or U-937 cells. Spleen or Tonsil.
  • Concentration: 0.1 mg/mL
  • Buffer: PBS, 0.1% BSA, 0.05% azide
  • Molecular Weight: 60 kDa
  • Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user
  • Shipping Conditions: Room temperature
  • Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
  • Shelf Life: 2 years

Datasheet

MSDS