α-Conotoxin MII (TFA)

α-Conotoxin MII (TFA)

• UNSPSC Description: α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].
• Target Antigen: nAChR
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: OC(C(F)(F)F)=O.O=C(N[C@@H](CSSC[C@@H](C(N)=O)NC1=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@H]1CC(C)C)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N5[C@@H](CCC5)C(N[C@H]4C(C)C)=O)=O)=O)=O)=O)CN
• Molecular Weight: 1710.94 (free base)
• References & Citations: [1]G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8.|[2]S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42.|[3]J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported