SphK1&2-IN-1

SphK1&2-IN-1

• CAS Number: 1415662-57-5
• UNSPSC Description: SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
• Target Antigen: SphK
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/sphk1-2-in-1.html
• Solubility: DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: COC1=C(C=CC(/C=C/C(NC2=NC=CS2)=O)=C1)OC
• Molecular Weight: 290.34
• References & Citations: [1]Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. |[2]Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported