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CD 10899

CAT: 0804-HY-160624Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160624Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD 10899 is a hydroxylated metabolite of Volasertib. CD 10899 is pharmacologically active against Polo-like kinase 1 (PLK1) (IC50: 6 nM). Volasertib is an orally active, highly potent and ATP-competitive PLK1 inhibitor. CD 10899 can be used for research of cancer[1].
CAS Number
1331770-20-7
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cd-10899.html
Solubility
10 mM in DMSO
Smiles
CC(N1C2=NC(NC3=C(C=C(C=C3)C(N[C@H]4CC[C@H](N5CCN(CC5)CC6CC6)CC4)=O)OC)=NC=C2N(C(C1(O)CC)=O)C)C
Molecular Formula
C34H50N8O4
Molecular Weight
634.81
References & Citations
[1]Lang I, et al. Potential Drug-Drug Interactions with Combination Volasertib + Itraconazole: A Phase I, Fixed-sequence Study in Patients with Solid Tumors. Clin Ther. 2020 Nov;42 (11) :2214-2224.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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