CD 10899

• Description :

  CD 10899 is a hydroxylated metabolite of Volasertib (HY-12137) . CD 10899 is pharmacologically active against Polo-like kinase 1 (PLK1) (IC50: 6 nM) . Volasertib is an orally active, highly potent and ATP-competitive PLK1 inhibitor. CD 10899 can be used for research of cancer[1].

• UNSPSC :

  12352005

• Target :

  Polo-like Kinase (PLK)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cd-10899.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(N1C2=NC(NC3=C(C=C(C=C3)C(N[C@H]4CC[C@H](N5CCN(CC5)CC6CC6)CC4)=O)OC)=NC=C2N(C(C1(O)CC)=O)C)C

• Molecular Formula :

  C34H50N8O4

• Molecular Weight :

  634.81

• References & Citations :

  [1]Lang I, et al. Potential Drug-Drug Interactions with Combination Volasertib + Itraconazole: A Phase I, Fixed-sequence Study in Patients with Solid Tumors. Clin Ther. 2020 Nov;42 (11) :2214-2224.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1331770-20-7]