RegisterLogin

CD-10

CAT: 804-HY-174395Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression[1].
UNSPSC
12352100
Target
Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=CC=C(C=C1)S(=O)(N(C2=CC=C(C3=CC=CC=C32)N(S(=O)(C4=CC=C(C=C4)NC(CCN5CCC6(CC5)CCOC6)=O)=O)CC(N)=O)CC(N)=O)=O
Molecular Formula
C38H44N6O9S2
Molecular Weight
792.92
References & Citations
[1]Chen Y, et, al. Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents. Eur J Med Chem. 2025 Jun 8;296:117848.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-17031-01SBE-β-CD
HY-137234-01DM-β-CD
HY-19047CD-349
HY-18593-01Mal-β-CD
HY-101103-01HP-β-CD
HY-160624CD 10899
HY-136476FCd (II) protoporphyrin IX
HY-161677PD-L1/CD-73-IN-1
HY-23499-01Indeno[1,2,3-cd]pyrene
HY-P3983[Cys (Bzl) 84] CD (81-92)

Alternative Products

CatalogName
T210818-01CD-10
CB-CALLACD Markers CD 10 (CALLA)
FR4D11CD Markers CD 10 (CALLA)
MBS684101-01Anti - CD 10
9146Clindamycin CD 10 µg
9146/1Clindamycin CD 10 µg
2646580Clindamycin CD 10 µg
3676-100CD-14 Antibody (Clone biG 10)
462357-01Phenanthro[1,10-cd][1,2]dithiole
TRC-P295035-100MGPhenanthro[1,10-cd][1,2]dithiole

Popular Products