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CRX-526

CAT: 0804-HY-118984Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118984Size:1 Each
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Description
CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model).
CAS Number
245515-64-4
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/crx-526.html
Smiles
O=C([C@H](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)OP(O)(O)=O)CO)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCC)=O)=O)O
Molecular Formula
C69H127N2O19P
Molecular Weight
1319.72
References & Citations
[1]Fort MM, et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol. 2005 May 15;174 (10) :6416-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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