LSN3074753

CAT: 0804-HY-164492Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-164492Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LSN3074753, an analog of LY3009120 , is a pan-RAF and Raf dimer inhibitor. LSN3074753 demonstrates activity against tumor cells with MAPK pathway activation driven by BRAF monomer or RAF dimers including BRAF- or KRAS-mutant colorectal cancer. LSN3074753 combined with Cetuximab (HY-P9905) shows additive and synergistic effects for colorectal cancer PDX models, particularly those with KRAS or BRAF mutation[1][2].

CAS Number

1455031-68-1

UNSPSC

12352005

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lsn3074753.html

Smiles

O=C(NC[C@@H](O)C(C)(C)C)NC1=CC(C2=CC3=CN=C(NC)C=C3N=C2C)=C(C)C=C1F

Molecular Formula

C24H30FN5O2

Molecular Weight

439.53

References & Citations

[1]Yao YM, et al. Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations. Clin Cancer Res. 2017 Sep 15;23 (18) :5547-5560.|[2]Sorokin A, et al. Antitumor activity of panRAF inhibition in BRAF V600E metastatic colorectal cancer[J]. 2017.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19237558-01	LSN3074753

LSN3074753

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