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LSN3074753

CAT: 0931-T89906-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89906-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1455031-68-1
Target
Ras, Raf, Kras
Related Pathways
MAPK
Bioactivity
LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound exhibits inhibitory activity against tumor cells driven by either BRAF monomers or RAF dimers, particularly in the activation of the MAPK pathway, including colorectal cancers with BRAF or KRAS mutations. When combined with Cetuximab, LSN3074753 demonstrates additive and synergistic effects in colorectal cancer PDX models, especially in those harboring KRAS or BRAF mutations.
Smiles
CC=1C(=CC2=C(N1)C=C(NC)N=C2)C3=CC(NC(NC[C@H](C(C)(C)C)O)=O)=C(F)C=C3C
Molecular Formula
C24H30FN5O2
Molecular Weight
439.53
Shipping Conditions
Ice Packs
Storage Temperature
-20��C

Alternative Products

CatalogName
HY-164492LSN3074753

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