Quinacrine

• Description :

  Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM) . Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) [1][2][3][4][7].

• Product Name Alternative :

  Acriquine

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335, H361, H373

• Target :

  Aldehyde Oxidase (AO) ; Apoptosis; DNA Stain; Parasite; Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/quinacrine.html

• Purity :

  98.20

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC

• Molecular Formula :

  C23H30ClN3O

• Molecular Weight :

  399.96

• Precautions :

  H302, H315, H319, H335, H361, H373

• References & Citations :

  [1]Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46 (17) :3563-4. |[2]Pryde DC, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53 (24) :8441-60. |[3]McNeal ET, et al. [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28 (3) :381-8. |[4]Caro AA, et al. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Sep 5;278 (36) :33866-77. |[5]Al Asmari AK, et al. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. BMC Nephrol. 2017 Jan 28;18 (1) :41. |[6]al Khader A, et al. Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats. Transplantation. 1996 Aug 27;62 (4) :427-35.|[7]Wu X, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73 (1-2) :52-64.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Citation 01 :

  J Neuroinflammation. 2025 Oct 27;22 (1) :243.|Phytomedicine. 2025 Jun 12:145:156981.|ACS Nano. 2020 Jun 23;14 (6) :7639-7650.|bioRxiv. 2025 Nov 11.|J Biomed Sci. 2025 Feb 5;32 (1) :15.|Part Fibre Toxicol. 2024 Mar 7;21 (1) :13.|Pharmaceutics. 2022 Jan 12;14 (1) :176.|University of Saskatchewan. 2020 Jun 22.

• CAS Number :

  [83-89-6]