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Quinacrine (Standard)

CAT: 0804-HY-13735R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13735R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quinacrine (Standard) is the analytical standard of Quinacrine. This product is intended for research and analytical applications. Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM) . Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) [1][2][3][4][7].
CAS Number
83-89-6
UNSPSC
12352100
Target
Apoptosis; DNA Stain; Parasite; Reference Standards; Sodium Channel
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others
Field of Research
Cancer; Infection; Neurological Disease
Smiles
CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC
Molecular Formula
C23H30ClN3O
Molecular Weight
399.96
References & Citations
[1]Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46 (17) :3563-4. |[2]Pryde DC, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53 (24) :8441-60. |[3]McNeal ET, et al. [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28 (3) :381-8. |[4]Caro AA, et al. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Sep 5;278 (36) :33866-77. |[5]Al Asmari AK, et al. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. BMC Nephrol. 2017 Jan 28;18 (1) :41. |[6]al Khader A, et al. Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats. Transplantation. 1996 Aug 27;62 (4) :427-35.|[7]Wu X, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73 (1-2) :52-64.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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