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S 17092

CAT: 0804-HY-15114-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15114-01Size:5 mg
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Description
S 17092 (S 17092-1) is an orally active cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 inhibits cell apoptosis. S 17092 mechanism of action is to inhibit the activity of PEP, slowing down the degradation of neuroactive peptides and thus enhancing memory function. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging[1][2][3].
CAS Number
176797-26-5
Product Name Alternative
S 17092-1
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-17092.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1[C@@](C2=CC=CC=C2)([H])C1)N3[C@]4([H])[C@](CCCC4)([H])C[C@H]3C(N5CCSC5)=O
Molecular Formula
C22H28N2O2S
Molecular Weight
384.53
Precautions
H302
References & Citations
[1]Philippe Morain, et al. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Rev. Spring 2002;8 (1) :31-52.|[2]Odaka C, et al. Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death. FEBS Lett. 2002 Feb 13;512 (1-3) :163-7.|[3]Di Daniel E, et al. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Mol Cell Neurosci. 2009 Jul;41 (3) :373-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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CatalogName
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