Doxorubicinone-d3
CAT:
804-HY-121309S-02
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Doxorubicinone-d3
- Product Name Alternative: Adriamycin aglycone-d3; Adriamycinone-d3
- UNSPSC Description: Doxorubicinone-d3 is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
- Target Antigen: Endogenous Metabolite
- Type: Isotope-Labeled Compounds
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Cancer
- Solubility: 10 mM in DMSO
- Smiles: OC1=C(C2=C(C(C3=O)=C1C(C4=CC=CC(OC([2H])([2H])[2H])=C34)=O)O)C[C@](O)(C[C@@H]2O)C(CO)=O
- Molecular Weight: 417.38
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]M Joerger, et al. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma. Cancer Chemother Pharmacol. 2005 May;55(5):488-96.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported