Elexacaftor-d3

• Description:

  Elexacaftor-d3 (VX-445-d3) is the deuterium labeled Elexacaftor (HY-111772) [1].

• Product Name Alternative:

  VX-445-d3

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.23

• Solubility:

  10 mM in DMSO|DMSO : ≥ 125mg/mL

• Smiles:

  CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C([2H])([2H])[2H])N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

• Molecular Formula:

  C26H31D3F3N7O4S

• Molecular Weight:

  600.67

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379 (17) :1612-1620.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported