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Doxorubicinone

CAT: 0804-HY-121309Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-121309Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
CAS Number
24385-10-2
Product Name Alternative
Adriamycin aglycone; Adriamycinone
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H340, H350, H360
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/doxorubicinone.html
Purity
98.29
Solubility
10 mM in DMSO
Smiles
OC1=C(C2=C(C(C3=O)=C1C(C4=CC=CC(OC)=C34)=O)O)C[C@](O)(C[C@@H]2O)C(CO)=O
Molecular Formula
C21H18O9
Molecular Weight
414.36
Precautions
H301, H311, H331, H340, H350, H360
References & Citations
[1]M Joerger, et al. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma. Cancer Chemother Pharmacol. 2005 May;55 (5) :488-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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FD22607-01Doxorubicinone
AR-D07741-01Doxorubicinone-d3
AR-D01298-01Doxorubicinone Valerate
443466Bromo Didehydro Doxorubicinone
163965Doxorubicinone-d3 discontinued
MBS6049057-01Doxorubicinone (Adriamycinone, Doxorubicin aglycone)
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