Thromboxane B3

• Description:

  Thromboxane B3 is a prostaglandin analog derived from arachidonic acid (AA) in the cyclooxygenase (COX) metabolic pathway. Thromboxane B3 is generated from arachidonic acid (AA) in platelets and vascular endothelial cells through the catalysis of cyclooxygenase (COX) and thromboxane synthase (TXS) . Thromboxane B3 has been reported to be formed by human platelets upon ingestion of eicosapentaenoic acid (C20: 5ω3) [1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  COX; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/thromboxane-b3.html

• Concentration:

  271.40 μM * 1 mL in Methyl acetate

• Purity:

  95.0

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)C/C=C\CC)OC(O)C[C@@H]1O

• Molecular Formula:

  C20H32O6

• Molecular Weight:

  368.46

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fischer S, et al. Thromboxane A3 (TXA3) is formed in human platelets after dietary eicosapentaenoic acid (C20: 5ω3) [J]. Biochemical and biophysical research communications, 1983, 116 (3) : 1091-1099.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [71953-80-5]