Thromboxane B2

CAT: 0804-HY-113331Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113331Size:1 mg
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Description
Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid[1][2][3].
CAS Number
[54397-85-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/thromboxane-b2.html
Purity
99.00
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C[C@@H]1O
Molecular Formula
C20H34O6
Molecular Weight
370.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Tada, M., et al., (1981) . Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris. Circulation, 64 (6), 1107–1115.|[2]Szczuko, M., et al., (2021) . The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review. International journal of molecular sciences, 22 (21), 11644.|[3]Wasserman, M. A., & Griffin, R. L. (1977) . Thromboxane B2--comparative bronchoactivity in experimental systems. European journal of pharmacology, 46 (4), 303–313.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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