Thromboxane B2

• Description:

  Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/thromboxane-b2.html

• Purity:

  99.00

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C[C@@H]1O

• Molecular Formula:

  C20H34O6

• Molecular Weight:

  370.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Tada, M., et al., (1981) . Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris. Circulation, 64 (6), 1107–1115.|[2]Szczuko, M., et al., (2021) . The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review. International journal of molecular sciences, 22 (21), 11644.|[3]Wasserman, M. A., & Griffin, R. L. (1977) . Thromboxane B2--comparative bronchoactivity in experimental systems. European journal of pharmacology, 46 (4), 303–313.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [54397-85-2]