RegisterLogin

Thromboxane A2

CAT: 0804-HY-113350Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-113350Size:Inquire
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
[57576-52-0]
UNSPSC Description
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2][3].
Target Antigen
Drug Metabolite; Endogenous Metabolite; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/thromboxane-a2.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@]2([H])O[C@@]1([H])C2
Molecular Weight
352.47
References & Citations
[1]Matthew A Sparks, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013 Jan;61(1):166-73.|[2]Federica Moalli, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.|[3]Nie D, et al. Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem Biophys Res Commun. 2000 Jan 7;267(1):245-51.
Shipping Conditions
Room temperature
Clinical Information
Phase 2

Related Products

CatalogName
HY-113445-01Thromboxane B3
HY-120980Thromboxane B1
HY-113331Thromboxane B2
HY-113331S1Thromboxane B2-d9
HY-177362Thromboxane B2 ethanolamide
HY-113331SThromboxane B2-d4
HY-113331FThromboxane B2-biotin
HY-12435311-Dehydro thromboxane B3
HY-11342011-Dehydro-thromboxane B2
HY-126923-012,3-Dinor thromboxane B2

Alternative Products

CatalogName
T73855-01Thromboxane B1
MBS6098281-01Thromboxane B2
MBS5784350Thromboxane A2
AP88503Thromboxane-A synthase
MBS8578457-01Thromboxane synthase
T84569-01Thromboxane B3
T211503-01Thromboxane B2-biotin
MBS616150-01Thromboxane B2 (TXB2)
TRC-C178783-5MGCarbocyclic Thromboxane A2
sc-201452CTXB2 (Thromboxane B2)

Popular Products