HG-14-10-04
CAT:
804-HY-15801-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HG-14-10-04
- CAS Number: 1356962-34-9
- UNSPSC Description: HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer[1][2].
- Target Antigen: Anaplastic lymphoma kinase (ALK); EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/HG-14-10-04.html
- Solubility: DMSO : 20 mg/mL (ultrasonic)
- Smiles: ClC1=CN=C(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)N=C1C5=CNC6=CC=CC=C65
- Molecular Weight: 532.08
- References & Citations: [1]U.S. Pat. Appl. Publ. (2012), US 20120028924 A1|[2]Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported