HG-10-102-01
CAT:
804-HY-13488-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HG-10-102-01
- CAS Number: 1351758-81-0
- UNSPSC Description: HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and MLK1, with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research[1][2].
- Target Antigen: LRRK2; MNK
- Type: Reference compound
- Related Pathways: Autophagy;MAPK/ERK Pathway
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/HG-10-102-01.html
- Smiles: COC1=CC(C(N2CCOCC2)=O)=CC=C1NC3=NC(NC)=C(Cl)C=N3
- Molecular Weight: 377.83
- References & Citations: [1]Choi HG, et al. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662.|[2]Wang M, et al. Synthesis of [11C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1351-1355.
- Shipping Conditions: Room Temperature