Coronarin A

• Description:

  Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

• UNSPSC:

  12352005

• Target:

  MTOR; Ribosomal S6 Kinase (RSK)

• Type:

  Natural Products

• Related Pathways:

  MAPK/ERK Pathway; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/coronarin-a.html

• Purity:

  98.0

• Smiles:

  C[C@@]1 ([C@H]2/C=C/C3=COC=C3) [C@@] (C (C) (CCC1) C) ([H]) C[C@H] (O) C2=C

• Molecular Formula:

  C20H28O2

• Molecular Weight:

  300.44

• References & Citations:

  [1]Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  MTORC1

• CAS Number:

  119188-33-9