Coronarin A

• Description :

  Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

• CAS Number :

  [119188-33-9]

• UNSPSC :

  12352005

• Target :

  MTOR; Ribosomal S6 Kinase (RSK)

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/coronarin-a.html

• Purity :

  98.0

• Smiles :

  C[C@@]1([C@H]2/C=C/C3=COC=C3)[C@@](C(C)(CCC1)C)([H])C[C@H](O)C2=C

• Molecular Formula :

  C20H28O2

• Molecular Weight :

  300.44

• References & Citations :

  [1]Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  MTORC1