Cis-Coronaric acid

• Description :

  Cis-Coronaric acid is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome. Mitochondrial dysfunction is the main feature of cis-Coronaric acid cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.

• Product Name Alternative :

  Cis-9,10-Epoxy-12 (Z) -octadecenoic acid

• UNSPSC :

  12352211

• Target :

  Endogenous Metabolite

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Others

• Smiles :

  CCCCC/C=C\C[C@H]1O[C@H]1CCCCCCCC(O)=O

• Molecular Formula :

  C18H32O3

• Molecular Weight :

  296.44

• References & Citations :

  [1]Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 Sep 11;115 (37) :9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23. PMID: 30139917; PMCID: PMC6140511.|[2]Hayakawa M, Sugiyama S, Takamura T, Yokoo K, Iwata M, Suzuki K, Taki F, Takahashi S, Ozawa T. Neutrophils biosynthesize leukotoxin, 9, 10-epoxy-12-octadecenoate. Biochem Biophys Res Commun. 1986 May 29;137 (1) :424-30. doi: 10.1016/0006-291x (86) 91227-1. PMID: 3718512.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [61949-82-4]