Oroxin A (Standard)

• Description :

  Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE) . Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].

• UNSPSC :

  12352005

• Target :

  Glycosidase; PPAR; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/oroxin-a-standard.html

• Smiles :

  O=C1C=C(C2=CC=CC=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(O)C(O)=C13

• Molecular Formula :

  C21H20O10

• Molecular Weight :

  432.38

• References & Citations :

  [1]Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34.|[2]He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27 (3) :204-15.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [57396-78-8]