PSAP Polyclonal Antibody

• Background :

  Prosaposin behaves as a myelinotrophic and neurotrophic factor, whose effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.By similarity Saposins are specific low-molecular mass non-enzymic proteins and participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. The Prosaposin gets cleaved into 5 chains, Saposin A, B, B-Val, C and D. It also contains several disulfide bonds as well as glycosylation sites.

• Abbreviation :

  PSAP

• UniProt :

  P07602

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant Human PSAP protein expressed by Mammalian

• Target :

  GLBA; prosaposin; SAP1; SAP; PSAP; GLBA; SAP1; proactivator polypeptide; prosaposin; SAP1p; PSA

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Signal Transduction; Metabolism

• Purification :

  Antigen Affinity Purification

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:1000-1:2000; IHC 1:500-1:1000

• Buffer :

  PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

• Calculated Molecular Weight :

  58 kDa

• Observed Molecular Weight :

  60-80 kDa

• Isotype :

  IgG