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Astressin 2B

CAT: 0804-HY-P1108-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1108-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC50 values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying[1][2][3].
CAS Number
681260-70-8
UNSPSC
12352209
Target
CFTR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/astressin-2b.html
Purity
97.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@](CC(C)C)(C)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@@H](NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCCC)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@](CC(C)C)(C)NC([C@H](CC1=CNC=N1)NC([C@@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC(N[C@@H](CC(N)=O)C(N[C@H]3CC(N)=O)=O)=O)=O)CCCCNC3=O
Molecular Formula
C183H307N49O53
Molecular Weight
4041.69
References & Citations
[1]Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45 (21) :4737-4747.|[2]Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26 (36) :9142-9152.|[3]Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26 (3) :457-470.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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