Interferon alfa-2b

• Description:

  Interferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Interferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3) . The driver genes are then further activated by ISGF-3 to achieve antiviral function[1].

• UNSPSC:

  12352203

• Target:

  IFNAR

• Type:

  Inhibitory Antibodies

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/interferon-alfa.html

• Purity:

  95.0

• Solubility:

  10 mM in DMSO

• Smiles:

  [Interferonalfa-2b]

• Molecular Weight:

  (20.7 kDa)

• References & Citations:

  [1]Park C, et al. Immune response in Stat2 knockout mice. Immunity. 2000 Dec;13 (6) :795-804.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4°C for 2 years, do not freeze

• Scientific Category:

  Inhibitory Antibodies

• Clinical Information:

  No Development Reported