AUNP-12

• Description :

  AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1].

• Product Name Alternative :

  NP-12

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H400, H410

• Target :

  PD-1/PD-L1

• Type :

  Peptides

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/np-12.html

• Purity :

  99.31

• Solubility :

  H2O : 10 mg/mL (ultrasonic)

• Smiles :

  OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCNC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C142H226N40O48

• Molecular Weight :

  3261.55

• Precautions :

  H302, H400, H410

• References & Citations :

  [1]Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18 (6) :1081-1091.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [1353563-85-5]