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α-Amylase-IN-12

CAT: 0804-HY-168495Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168495Size:1 Each
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Description
α-Amylase-IN-12 (Compound 5e) is an α-amylase inhibitor (IC50: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC50 of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes[1].
CAS Number
1799667-33-6
UNSPSC
12352005
Target
Amylases; Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(OC(C1=CC=CC=C1)=N/2)C2=C\C3=CC=C(O)C(O)=C3
Molecular Formula
C16H11NO4
Molecular Weight
281.26
References & Citations
[1]Jayasinghe R N, et al. Evaluation of In Silico and In Vitro Antidiabetic Properties of 4- (Hydroxysubstituted Arylidene) -2-Phenyloxazol-5 (4 H) -one Derivatives. ACS Omega, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(4Z)-4-[(3,4-dihydroxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
CAS Number1799667-33-6
PubChem CID71674036
IUPAC Name(4Z)-4-[(3,4-dihydroxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
Molecular FormulaC16H11NO4
Molecular Weight281.26
XLogP2.9
Topological Polar Surface Area79.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity465
SMILES
C1=CC=C(C=C1)C2=N/C(=C\C3=CC(=C(C=C3)O)O)/C(=O)O2
InChI
InChI=1S/C16H11NO4/c18-13-7-6-10(9-14(13)19)8-12-16(20)21-15(17-12)11-4-2-1-3-5-11/h1-9,18-19H/b12-8-
InChIKey
MYSOXERGEXUHQJ-WQLSENKSSA-N
Chemical Structure
2D Structure
2D structure of (4Z)-4-[(3,4-dihydroxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
CAS: 1799667-33-6
CID: 71674036
Formula: C16H11NO4
MW: 281.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.26
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass281.06880783
Monoisotopic Mass281.06880783
Topological Polar Surface Area79.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity465
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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