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Harpagoside

CAT: 0804-HY-N0396-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0396-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) [1][2][3].
CAS Number
19210-12-9
UNSPSC
12352005
Hazard Statement
H302
Target
COX; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/harpagoside.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2OC=C[C@]3(O)[C@@]2([H])[C@@](C)(OC(/C=C/C4=CC=CC=C4)=O)C[C@H]3O)O[C@@H]1CO
Molecular Formula
C24H30O11
Molecular Weight
494.49
Precautions
H302
References & Citations
[1]Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24 (9) :1365-9.|[2]Huang TH, et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. J Ethnopharmacol. 2006 Mar 8;104 (1-2) :149-55.|[3]Li J, et al. Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways. Neuroscience. 2015 Sep 10;303:103-14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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