Lamin A + Lamin C Recombinant Mouse Monoclonal Antibody [A6F5-R]

Lamin A + Lamin C Recombinant Mouse Monoclonal Antibody [A6F5-R]

• Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
• Product Name Alternative: 70 kDa lamin antibody CDDC antibody EMD2 antibody FPL antibody FPLD antibody HGPS antibody IDC antibody LAMIN A antibody lamin A/C antibody LAMIN C antibody Lamin-A/C antibody LDP1 antibody LFP antibody LMN 1 antibody LMN A antibody LMN C antibody LMNA antibody LMNA_HUMAN antibody LMNC antibody PRO1 antibody Renal carcinoma antigen NY-REN-32 antibody
• Abbreviation: Lamin A/C
• CAS Number: 9000-83-3
• Swiss Prot: P02545 Human, P48678 Mouse, P48679 Rat
• Cellular Locus: Nucleus, Nucleus envelope, Nucleus lamina, Nucleoplasm, Nucleus matrix; Nucleus speckle.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Lamin A/C aa 151-350/664.
• Isotype: IgG1
• Clone: A6F5-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: HeLa cell lysate, HepG2 cell lysate, THP-1 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysates, HeLa, human breast tissue, human kidney tissue, human skin tissue, mouse colon tissue, rat heart tissue, rat small intestine tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:200-1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 74/65 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes