Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20]

Lamin A/C Recombinant Rabbit Monoclonal Antibody [PSH05-20]

• Description: A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, is comprised of ICE, CPP32, ICH-1/Nedd-2, Tx, Mch2, Mch3 (ICE-LAP3 or CMH-1), Mch4 and ICE-LAP6. Ced-3/ICE family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family. Lamin C is a splice variant of Lamin A, differing only at the carboxy-terminus. Lamins A and C are identical for the first 566 amino acids, with Lamin C differing only in six unique carboxy-terminal amino acids.
• Product Name Alternative: 70 kDa lamin antibody Cardiomyopathy dilated 1A (autosomal dominant) antibody CDCD1 antibody CDDC antibody CMD1A antibody CMT2B1 antibody EMD2 antibody FPL antibody FPLD antibody FPLD2 antibody HGPS antibody IDC antibody Lamin A antibody Lamin A/C antibody Lamin A/C like 1 antibody Lamin antibody Lamin C antibody Lamin-A/C antibody LDP1 antibody LFP antibody LGMD1B antibody Limb girdle muscular dystrophy 1B (autosomal dominant) antibody LMN 1 antibody LMN A antibody LMN C antibody LMN1 antibody LMNA antibody LMNA_HUMAN antibody LMNC antibody LMNL1 antibody Prelamin A/C antibody PRO1 antibody Renal carcinoma antigen NY REN 32 antibody Renal carcinoma antigen NY-REN-32 antibody Renal carcinoma antigen NYREN32 antibody
• Abbreviation: LMNA, LMN1
• CAS Number: 9000-83-3
• Swiss Prot: P02545 Human, P48678 Mouse, P48679 Rat
• Cellular Locus: Intermediate filament, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide.
• Isotype: IgG
• Clone: PSH05-20
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: HeLa cell lysate, HepG2 cell lysate, HeLa, human breast tissue, human skin tissue, human colon tissue, mouse colon tissue, rat colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:200-1:5,000 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 74 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes