Lamin B Receptor / LBR Recombinant Rabbit Monoclonal Antibody [PSH02-93]

Lamin B Receptor / LBR Recombinant Rabbit Monoclonal Antibody [PSH02-93]

• Description: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis . Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane.
• Product Name Alternative: DHCR 14B antibody DHCR14B antibody Integral nuclear envelope inner membrane protein antibody Lamin-B receptor antibody LBR antibody LBR_HUMAN antibody LMN 2R antibody LMN2R antibody MGC9041 antibody PHA antibody PRO0650 antibody
• Abbreviation: Delta-14-SR 3-beta-hydroxysterol Delta (14)-reductase 1 Publication C-14 sterol reductase (C14SR) Integral nuclear envelope inner membrane protein 1 Publication LMN2R Lamin-B receptor 2 Publications Sterol C14-reductase
• CAS Number: 9000-83-3
• Swiss Prot: Q14739 Human
• Cellular Locus: Nucleus inner membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within human Lamin B Receptor/LBR aa 1-500 / 615.
• Isotype: IgG
• Clone: PSH02-93
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: HEK-293 cell lysate, HeLa cell lysate, Jurkat cell lysate, HEK-293, human small intestine tissue, human testis tissue.
• Concentration: 1 mg/mL
• Dilution: WB:1:2,000 ;IHC-P:1:1,000-10,000 ;IF-Cell:1:2,000 ;FC:1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 71 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes