HSP60 (LK2), 0.2mg/mL

Recognizes a 60 kDa protein, identified as the heat shock protein 60 (hsp60) . Its epitope is localized between aa 383-419 of human hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (HSPs), more appropriately called as stress response proteins (SRPs) . hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone LK1, unlike LK2, recognizes only the mammalian (not bacterial) hsp60 and is useful in distinguishing hsp60 from mammals and bacteria.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

60kDa chaperonin; 60kDa heat shock protein mitochondrial; Chaperonin; 60-KD (CPN60) ; GROEL; HLD4; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; Short heat shock protein 60 Hsp60s1; Spastic paraplegia 13 (SPG13)

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

HSPD1

3329

595053

P10809

P10809

HSP60

Recombinant human HSP60 protein

HSP60

LK2

Primary

Animal

Animal

IF (verified) |IHC, FFPE (verified) |WB (verified)

Autoimmunity, Heat shock proteins, Immunology, Inflammation

HeLa or HepG2 cells. Synovial biopsies from patients with juvenile chronic arthritis. Synovial lining layer is strongly positive for hsp60. Breast carcinoma.

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

60 kDa

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2a, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)