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PNU-107484A

CAT: 0804-HY-117106Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117106Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes[1].
CAS Number
200266-76-8
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pnu-107484a.html
Smiles
CN1C2=NC(N3CCCC3)=NC(N4CCCC4)=C2C5=C1C=CN=C5.Cl
Molecular Formula
C18H23ClN6
Molecular Weight
358.87
References & Citations
[1]Im HK, et al. PNU-107484A with alpha isoform-dependent functional changes in alpha (x) beta2gamma2 subtypes of rat recombinant GABA (A) receptors. Br J Pharmacol. 1997 Nov;122 (5) :821-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Pnu-107484A

GABA(A) receptor ligand; structure in first source

CAS Number200266-76-8
PubChem CID9841749
IUPAC Name8-methyl-3,5-dipyrrolidin-1-yl-4,6,8,12-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene;hydrochloride
Molecular FormulaC18H23ClN6
Molecular Weight358.9
Topological Polar Surface Area50.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity447
SMILES
CN1C2=C(C=NC=C2)C3=C1N=C(N=C3N4CCCC4)N5CCCC5.Cl
InChI
InChI=1S/C18H22N6.ClH/c1-22-14-6-7-19-12-13(14)15-16(22)20-18(24-10-4-5-11-24)21-17(15)23-8-2-3-9-23;/h6-7,12H,2-5,8-11H2,1H3;1H
InChIKey
NUPWOBTZHLNAGL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pnu-107484A
CAS: 200266-76-8
CID: 9841749
Formula: C18H23ClN6
MW: 358.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight358.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass358.1672725
Monoisotopic Mass358.1672725
Topological Polar Surface Area50.1 Ų
Heavy Atom Count25
Formal Charge0
Complexity447
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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