Desethyl chloroquine (diphosphate)

Desethyl chloroquine (diphosphate)

• CAS Number: 247912-76-1
• UNSPSC Description: Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].
• Target Antigen: Autophagy; Parasite; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy;Immunology/Inflammation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/desethyl-chloroquine-diphosphate.html
• Smiles: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC.O=P(O)(O)O.O=P(O)(O)O
• Molecular Weight: 487.81
• References & Citations: [1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
• Shipping Conditions: Room Temperature