Desethyl chloroquine (diphosphate)
CAT:
804-HY-135811A-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Desethyl chloroquine (diphosphate)
- CAS Number: 247912-76-1
- UNSPSC Description: Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].
- Target Antigen: Autophagy; Parasite; Toll-like Receptor (TLR)
- Type: Reference compound
- Related Pathways: Anti-infection;Autophagy;Immunology/Inflammation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/desethyl-chloroquine-diphosphate.html
- Smiles: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC.O=P(O)(O)O.O=P(O)(O)O
- Molecular Weight: 487.81
- References & Citations: [1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
- Shipping Conditions: Room Temperature