Desethyl chloroquine (Standard)

• UNSPSC Description:

  Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

• Target Antigen:

  Autophagy; Parasite; Toll-like Receptor (TLR)

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Autophagy;Immunology/Inflammation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/desethyl-chloroquine-standard.html

• Smiles:

  CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC

• Molecular Weight:

  291.82

• References & Citations:

  [1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

• Shipping Conditions:

  Room temperature

• CAS Number:

  1476-52-4