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Carbamazepine

CAT: 0804-HY-B0246-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0246-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM) . Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain[1][2][3].
CAS Number
298-46-4
Product Name Alternative
CBZ; NSC 169864
UNSPSC
12352005
Hazard Statement
H302, H317, H336, H360
Target
Autophagy; Calcium Channel; HDAC; Mitophagy; Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Carbamazepine.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(N1C2=CC=CC=C2C=CC3=CC=CC=C31)N
Molecular Formula
C15H12N2O
Molecular Weight
236.27
Precautions
H302, H317, H336, H360
References & Citations
[1]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22 (3) : p. 627-35.|[2]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28 (2) : p. 143-53.|[3]Beutler AS, et al. Carbamazepine is an inhibitor of histone deacetylases. Life Sci. 2005 May 13;76 (26) :3107-15.|[4]Turpin E, et al. Carbamazepine directly inhibits adipocyte differentiation through activation of the ERK 1/2 pathway. Br J Pharmacol. 2013 Jan;168 (1) :139-50.|[5]Wang CH, et al. Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells. Pharm Biol. 2014 Nov;52 (11) :1451-9. |[6]Kawaguchi T, et al. Carbamazepine promotes liver regeneration and survival in mice. J Hepatol. 2013 Dec;59 (6) :1239-45.|[7]Kara NZ, et al. Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. Acta Neuropsychiatr. 2014 Feb;26 (1) :29-34.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
B1390-50Carbamazepine

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