Carbamazepine

• Description :

  Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM) . Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain[1][2][3].

• Product Name Alternative :

  CBZ; NSC 169864

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317, H336, H360

• Target :

  Autophagy; Calcium Channel; HDAC; Mitophagy; Potassium Channel; Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Carbamazepine.html

• Purity :

  99.95

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C2=CC=CC=C2C=CC3=CC=CC=C31)N

• Molecular Formula :

  C15H12N2O

• Molecular Weight :

  236.27

• Precautions :

  H302, H317, H336, H360

• References & Citations :

  [1]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22 (3) : p. 627-35.|[2]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28 (2) : p. 143-53.|[3]Beutler AS, et al. Carbamazepine is an inhibitor of histone deacetylases. Life Sci. 2005 May 13;76 (26) :3107-15.|[4]Turpin E, et al. Carbamazepine directly inhibits adipocyte differentiation through activation of the ERK 1/2 pathway. Br J Pharmacol. 2013 Jan;168 (1) :139-50.|[5]Wang CH, et al. Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells. Pharm Biol. 2014 Nov;52 (11) :1451-9. |[6]Kawaguchi T, et al. Carbamazepine promotes liver regeneration and survival in mice. J Hepatol. 2013 Dec;59 (6) :1239-45.|[7]Kara NZ, et al. Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. Acta Neuropsychiatr. 2014 Feb;26 (1) :29-34.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [298-46-4]