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Carbamazepine-d8

CAT: 0804-HY-B0246S2-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0246S2-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].
CAS Number
1538624-35-9
Product Name Alternative
CBZ-d8; NSC 169864-d8
UNSPSC
12352005
Hazard Statement
H302-H317-H334
Target
Autophagy; Isotope-Labeled Compounds; Mitophagy; Sodium Channel
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Purity
98.70
Solubility
10 mM in DMSO
Smiles
NC(N1C2=C([2H])C([2H])=C([2H])C=C2C([2H])=C([2H])C3=CC([2H])=C([2H])C([2H])=C31)=O
Molecular Formula
C15H4D8N2O
Molecular Weight
244.32
Precautions
P261-P264-P270-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22 (3) : p. 627-35.|[2]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28 (2) : p. 143-53.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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