GPNA (hydrochloride)

• UNSPSC Description:

  GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].

• Target Antigen:

  Apoptosis; ASCT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gpna-hydrochloride.html

• Purity:

  99.91

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC([C@@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl

• Molecular Weight:

  303.702

• References & Citations:

  [1]Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.Antioxidants (Basel). 2021, 10(9), 1349.|Clin Respir J. 2024 Aug;18(8):e13825.|Front Pharmacol. 2022 Feb 23;13:816133.|Front Pharmacol. 23 February 2022.|Int Immunopharmacol. 2023 Apr 26;119:110216.|Tohoku J Exp Med. 2024 Jun 13.|Biochem Pharmacol. 2023 Aug 25;115767.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  67953-08-6