Products for Research Use Only
RegisterLogin

GPNA (hydrochloride)

CAT: 0804-HY-W011391-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W011391-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT) . GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
CAS Number
67953-08-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; ASCT
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpna-hydrochloride.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC([C@@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl
Molecular Formula
C11H14ClN3O5
Molecular Weight
303.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9 (1) :891.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ASCT2
Citation 01
Adv Sci (Weinh) . 2025 Aug 10:e07057.|Antioxidants (Basel) . 2021 Aug 25;10 (9) :1349.|Clin Respir J. 2024 Aug;18 (8) :e13825.|Front Pharmacol. 2022 Feb 23:13:816133.|Front Pharmacol. 2022 Feb 23;13:816133.|Int Immunopharmacol. 2023 Jun:119:110216.|Tohoku J Exp Med. 2024 Nov 14;264 (1) :31-39.|Biochem Pharmacol. 2023 Oct:216:115767.

Related Products

CatalogName
HY-B0500BAlverine (hydrochloride)
HY-W714513VU0469650 (hydrochloride)
HY-W708286-01α-Pyrrolidinobutiothiophenone (hydrochloride)
HY-W492795Quifenadine (hydrochloride)
HY-W012179-01Phenylpiperazine (hydrochloride)
HY-Z6449-01Phenylephrone (hydrochloride)
HY-W209279(±) Anabasine (hydrochloride)
HY-W027446-01Pyridoxal hydrochloride
HY-W011963-01Melevodopa (hydrochloride)
HY-N0093-01Ancitabine (hydrochloride)

Alternative Products

CatalogName
OR1023343-01Gpna (Hydrochloride)
C12111-100mgGPNA hydrochloride
A22452-5GPNA hydrochloride 5mg
A22452-10GPNA hydrochloride 10mg
A22452-500GPNA hydrochloride 500mg
A22452-25GPNA hydrochloride 25mg
A22452-100GPNA hydrochloride 100mg
A22452-50GPNA hydrochloride 50mg
B2150-250GPNA (monohydrate)
105415-01L-γ-Glutamyl-p-Nitroanilide Monohydrate [GPNA, L-Glutamic Acid 1- (4-Nitroanilde) ] for Biochemistry

Popular Products