PCBD1 Recombinant Rabbit Monoclonal Antibody [JE62-75]

PCBD1 Recombinant Rabbit Monoclonal Antibody [JE62-75]

• Description: This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription.
• Alternative Name: 4 alpha hydroxy tetrahydropterin dehydratase antibody 4-alpha-hydroxy-tetrahydropterin dehydratase antibody 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody DCoH antibody Dimerization cofactor of hepatic nuclear factor 1 alpha antibody Dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody Dimerization cofactor of hepatocyte nuclear factor 1-alpha antibody Dimerization cofactor of HNF1 antibody Dimerizing cofactor for HNF1 antibody PCBD 1 antibody PCBD antibody PCBD1 antibody PCD antibody Phenylalanine hydroxylase stimulating protein antibody Phenylalanine hydroxylase-stimulating protein antibody PHS antibody PHS_HUMAN antibody Pterin 4 alpha carbinolamine dehydratase antibody Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody Pterin carbinolamine dehydratase antibody Pterin-4-alpha-carbinolamine dehydratase antibody
• Abbreviation: Pterin-4-alpha-carbinolamine dehydratase PHS 4-alpha-hydroxy-tetrahydropterin dehydratase Dimerization cofactor of hepatocyte nuclear factor 1-alpha (DCoH; Dimerization cofactor of HNF1) Phenylalanine hydroxylase-stimulating protein Pterin carbinolamine dehydratase (PCD) PCBD1 DCOH, PCBD
• Swiss Prot: P61457 Human, P61458 Mouse, P61459 Rat
• Cellular Locus: Cytoplasm. Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human PCBD1 aa 1-104.
• Isotype: IgG
• Clone: JE62-75
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Caco-2 cell lysate, HEK-293 cell lysate, A549 cell lysate, HepG2 cell lysate, human colon tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 12 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes