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IST-622

CAT: 0804-HY-159803Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159803Size:1 Each
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Description
IST-622 (6-O- (3-Ethoxypropionyl) -3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4) . IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT[1].
CAS Number
128201-92-3
Product Name Alternative
6-O- (3-Ethoxypropionyl) -3',4'-O-exo-benzylidenechartreusin
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ist-622.html
Smiles
CCOCCC(OC1=C(C=CC=C2O[C@H]3[C@@H]([C@]4([H])[C@](O[C@H](C5=CC=CC=C5)O4)([H])[C@H](O3)C)O[C@@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)OC)O)C2=C(OC(C7=C(C)C=CC(O8)=C79)=O)C9=C1C8=O)=O
Molecular Formula
C44H44O16
Molecular Weight
828.81
References & Citations
[1]Antitumor effects of IST-622, a novel synthetic derivative of chartreusin, against murine and human tumor lines following oral administration
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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