CLK1-IN-3

CLK1-IN-3

• CAS Number: 2922550-28-3
• UNSPSC Description: CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].
• Target Antigen: Autophagy; CDK; DYRK
• Type: Reference compound
• Related Pathways: Autophagy;Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/clk1-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O
• Molecular Weight: 430.48
• References & Citations: [1]Yang T, et al. Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI). Eur J Med Chem. 2023 Mar 15;250:115168.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported