rel-(R,R)-THC

rel-(R,R)-THC

• CAS Number: 138090-06-9
• UNSPSC Description: rel-(R,R)-THC is the relative configuration of (R,R)-THC (HY-103451). (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/rel-r-r-thc.html
• Smiles: CC[C@H]1C2=C([C@@H](CC3=CC(O)=CC=C32)CC)C4=CC=C(O)C=C4C1
• Molecular Weight: 320.42
• References & Citations: [1]Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported