NLRP3-IN-13

NLRP3-IN-13

• CAS Number: 1704638-35-6
• UNSPSC Description: NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC50: 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders[1].
• Target Antigen: NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nlrp3-in-13.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C1OC2=C(N1CC(NCC3=CN=CC(C4=CSC=C4)=C3)=O)C=CC=C2
• Molecular Weight: 365.41
• References & Citations: [1]Devita Robert, et al. Benzoxazolones as inhibitors of inflammasomes and their preparation. Patent. WO2022187804.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported