Phosphotyrosine

• Background:

  The role of tyrosine phosphorylation in transduction of the mitogenic signal from transmembrane receptors and in transformation by oncogene tyrosine kinases has been the subject of intense investigation for several years. While the phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. Antibodies that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine -phosphorylated proteins and the biochemical pathways in which they function.

• Host:

  Mouse

• Isotype:

  IgG2b

• Clone:

  PY20

• Type:

  Monoclonal Antibody

• Applications:

  WB, IP, Enzyme Immunoassay, IHC

• Field of Research:

  Signal Transduction

• Assay Principle:

  Western Blot|Immunoprecipitation|Enzyme Immunoassay|Immunohistochemistry

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Shipping Conditions:

  Ambient Temperature, do not freeze, refrigerate upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles