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(2Z,3Z) -U0126

CAT: 0804-HY-12031BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12031BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(2Z,3Z) -U0126 is a selective inhibitor of MEK1 and MEK2, demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z,3Z) -U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally, (2Z,3Z) -U0126 can undergo isomerization and cyclization, resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.
CAS Number
218601-62-8
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2z-3z-u0126.html
Smiles
NC(C=CC=C1)=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=C(C=CC=C2)N
Molecular Formula
C18H16N6S2
Molecular Weight
380.49
References & Citations
[1]MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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