(2Z,3Z) -U0126

CAT: 0931-T69826-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T69826-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

218601-62-8

Target

Others, MEK

Related Pathways

MAPK, Others

Bioactivity

(2Z,3Z) -U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.

Smiles

C(/C(=C(/SC1=C(N)C=CC=C1)\N)/C#N)(=C(\SC2=C(N)C=CC=C2)/N)\C#N

Molecular Formula

C18H16N6S2

Molecular Weight

380.49

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T21332-01	U0126
T6223-01	U0126-EtOH
TN7921-01	(2Z,13Z) -Octadecadienyl acetate
TN5828	(2Z,6Z,10E,14E,18E) -Farnesylfarnesol
T9834-01	(3Z) -1-methyl-3-[2- (4-methylphenyl) -2-oxo-ethylidene]piperazin-2-one
T125738-01	2-[ (1R,2R) -3-oxo-2-[ (2Z) -5- (sulfooxy) pent-2-en-1-y
T23484	U0124
TYD-03051-01	6-{ (1S,5S) -4-Oxo-5-[ (2Z) -pent-2-en-1-yl]cyclopent-2-en-1-yl}hexanoyl-CoA

Alternative Products

Catalog	Name
HY-12031B	(2Z,3Z) -U0126
RG-B091902-01	(2Z,3Z) -2,3-bis (amino ((2-aminophenyl) thio) methylene) succinonitrile/U0126
BA2003-10	U0126
sc-335642	(2Z,3Z) -2- (hydroxyimino) -N-phenyl-3- (phenylhydrazono) butanamide

(2Z,3Z) -U0126

Related Products

Alternative Products

Popular Products