U0126

• Description:

  U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Autophagy; Influenza Virus; MEK; Mitophagy

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Autophagy; MAPK/ERK Pathway

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/u-0126.html

• Purity:

  98.57

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  NC1=CC=CC=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=CC=CC=C2N

• Molecular Formula:

  C18H16N6S2

• Molecular Weight:

  380.49

• Precautions:

  H302

• References & Citations:

  [1]Favata MF, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273 (29) :18623-32.|[2]Droebner K, et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011, 92 (2), 195-203.|[3]Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11;27 (40) :5315-25.|[4]Ahnstedt H, et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar;35 (3) :454-60.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MEK1; MEK2

• Citation 01:

  Acta Biomater. 2021 May:126:183-198.|Adv Sci (Weinh) . 2024 Dec 27:e2408688.|Adv Sci (Weinh) . 2024 Jun 3:e2400023.|Adv Sci (Weinh) . 2024 Mar;11 (10) :e2308072.|Adv Sci (Weinh) . 2024 Nov 20:e2407662.|Am J Pathol. 2024 Aug 31:S0002-9440 (24) 00328-6.|Am J Physiol Cell Physiol. 2022 Jul 1;323 (1) :C133-C144.|Antioxidants (Basel) . 2021 Jun 29;10 (7) :1049.|Antioxidants (Basel) . 2024 Apr 27, 13 (5), 538.|Aquaculture. 2024 Jan 30, 579, 740209.|Arch Biochem Biophys. 2023 Mar 1:736:109525.|Biochem Pharmacol. 2023 Apr:210:115489.|Biochem Pharmacol. 2023 Jul:213:115595.|Biochem Pharmacol. 2024 Feb:220:116015.|Biochem Pharmacol. 2024 May:223:116194.|Biol Trace Elem Res. 2024 Feb;202 (2) :493-503.|Biomark Res. 2025 May 7;13 (1) :70.|Biomed Environ Sci. 2020 May 20;33 (5) :323-330. |Biomed Pharmacother. 2020 Sep;129:110384.|Biomed Pharmacother. 2024 May:174:116489.|bioRxiv. 2023 Apr 18.|bioRxiv. 2025 January 22.|bioRxiv. 2025 Jun 24:2025.06.18.660406.|bioRxiv. 2025 Sep 29.|Cancer Biol Ther. 2022 Dec 31;23 (1) :1-11.|Cancer Commun (Lond) . 2024 Nov;44 (11) :1350-1373.|Cancer Lett. 2024 May 25:216994.|Cancer Sci. 2021 Mar;112 (3) :997-1010.|Cancers. 2020 Jul 1;12 (7) :1756.|Cardiovasc Res. 2023 Aug 7;119 (9) :1811-1824.|Cell Commun Signal. 2025 Jan 13;23 (1) :22.|Cell Death Dis. 2021 Jun 2;12 (6) :570.|Cell Death Dis. 2021 Jun 7;12 (6) :582.|Cell Death Dis. 2021 May 18;12 (6) :510.|Cell Death Dis. 2022 Aug 19;13 (8) :724.|Cell Death Discov. 2020 Jul 6;6:56.|Cell Death Discov. 2022 Aug 17;8 (1) :365.|Cell Death Discov. 2024 Oct 29;10 (1) :459.|Cell Mol Gastroenterol Hepatol. 2024 Dec 30:101454.|Cell Mol Life Sci. 2021 Feb;78 (3) :949-962.|Cell Mol Life Sci. 2023 Nov 25;80 (12) :372.|Cell Prolif. 2021 Jun;54 (6) :e13048.|Cell Rep Med. 2025 Jan 16:101922.|Cell Rep Med. 2025 Sep 16;6 (9) :102324.|Cell Rep. 2024 Apr 23;43 (4) :114088.|Cell Signal. 2021 Sep:85:110060.|Cell Signal. 2025 Apr 19:111815.|Cell Signal. 2025 Jan 2:111587.|Cell Signal. 2025 Jul:131:111730.|Chem Biol Interact. 2024 Dec 1:404:111270.|Chem Biol Interact. 2024 May 17:111062.|Chin Med J (Engl) . 2025 Jan 17.|Clin Exp Ophthalmol. 2025 Jul 14.|Clin Mol Hepatol. 2023 Apr;29 (2) :465-481.|Clin Sci. 2021 Jul 16;135 (13) :1591-1608.|Colloids Surf B Biointerfaces. 2022 Feb:210:112229.|Commun Biol. 2024 Nov 5;7 (1) :1438.|Curr Res Food Sci. 2023 Jan 16:6:100447.|Curr Res Toxicol. 2024 Oct 24:7:100199.|Dig Dis Sci. 2023 May;68 (5) :1847-1857.|Discov Oncol. 2025 Jun 20;16 (1) :1167.|DNA Cell Biol. 2024 Sep;43 (9) :474-481.|Drug Des Devel Ther. 2025 Apr 1:19:2433-2452.|Drug Dev Res. 2025 Nov;86 (7) :e70183.|Ecotoxicol Environ Saf. 2024 Nov 1:286:117095.|eGastroenterology. 2025 Feb 12;3 (1) :e100173.|EMBO J. 2025 Mar;44 (5) :1464-1487.|Endocr Relat Cancer. 2023 Jul 25;30 (9) :e230130.|Environ Toxicol. 2025 Jan;40 (1) :88-100.|Eur J Pharmacol. 2021 Sep 5:906:174270.|Eur J Pharmacol. 2022 Jul 5:926:175034.|Eur J Pharmacol. 2023 Jan 5:938:175411.|Exp Cell Res. 2022 Dec 1;421 (1) :113374.|Exp Hematol Oncol. 2024 Oct 1;13 (1) :97.|Exp Mol Med. 2021 Sep;53 (9) :1366-1378.|Expert Opin Ther Targets. 2024 May;28 (5) :461-471.|FASEB J. 2025 Sep 30;39 (18) :e71045.|Food Funct. 2021 May 21;12 (10) :4556-4569.|Free Radic Biol Med. 2021 Jun:169:122-136.|Front Biosci (Landmark Ed) . 2023 Dec 1;28 (12) :325.|Front Immunol. 2021 Jul 28:12:688294.|Genes Cells. 2023 Sep;28 (9) :653-662.|Genes Dis. 2020 Nov 21;8 (6) :867-881.|Genes Dis. 2025 Nov 6.|Gerontology. 2023;69 (5) :615-627.|Geroscience. 2024 Oct;46 (5) :4373-4396.|Glia. 2023 Jul;71 (7) :1648-1666.|Hong Kong University of Science and Technology. 2025.|Hum Mol Genet. 2021 May 29;30 (10) :865-879.|Immunity. 2021 Sep 14;54 (9) :2042-2056.e8.|Int Immunopharmacol. 2022 Oct:111:109171.|Int Immunopharmacol. 2024 Sep 19;142 (Pt B) :113151.|Int Immunopharmacol. 2025 Jan 1:147:113955.|Int J Biochem Cell Biol. 2021 Aug:137:106036.|Int J Mol Sci. 2021 May 26;22 (11) :5675.|Int J Mol Sci. 2023 Apr 10;24 (8) :7012.|Int J Mol Sci. 2025 Jul 30;26 (15) :7361.|Invest Ophthalmol Vis Sci. 2020 Jul 1;61 (8) :28.|iScience. 2024 Mar 26.|iScience. 2024 Oct 30;27 (12) :111290.|J Adv Res. 2025 Jun 13:S2090-1232 (25) 00435-7.|J Agric Food Chem. 2024 Jun 7.|J Cardiothorac Surg. 2021 May 10;16 (1) :127.|J Cell Biochem. 2025 Apr;126 (4) :e70031.|J Cell Mol Med. 2025 Jun;29 (11) :e70624.|J Cell Physiol. 2021 Aug;236 (8) :5725-5741.|J Dermatol Sci. 2025 Sep 7:S0923-1811 (25) 00148-3.|J Exp Clin Cancer Res. 2021 Jan 4;40 (1) :4.|J Exp Clin Cancer Res. 2022 Feb 22;41 (1) :73.|J Immunother Cancer. 2024 Oct 23;12 (10) :e010148.|J Immunother Cancer. 2025 Jan 4;13 (1) :e010183.|J Infect Dis. 2024 Nov 18:jiae559.|J Inflamm Res. 2021 Apr 27:14:1633-1645.|J Integr Agric. 2023 Feb 24.|J Integr Neurosci. 2025 Aug 26;24 (8) :42286.|J Invest Dermatol. 2022 Oct;142 (10) :2591-2602.e8.|J Mater Sci Technol. 2024 Jan 24.|J Mol Med (Berl) . 2025 Oct 15.|J Orthop Translat. 2025 Apr 25:52:233-248.|J Orthop Translat. 2025 Jun 18:53:112-125.|J Pharm Pharmacol. 2025 Aug 4:rgaf052.|J Pineal Res. 2022 Nov;73 (4) :e12833.|J Sci Food Agric. 2024 Mar 15;104 (4) :2518-2525.|J Surg Res. 2023 Jun:286:118-126.|J Transl Med. 2023 Nov 21;21 (1) :838.|J Virol. 2021 Feb 24;95 (10) :e02436-20.|J Virol. 2024 Feb 20;98 (2) :e0194823.|J Virol. 2025 Aug 19;99 (8) :e0064925.|JCI Insight. 2022 May 23;7 (10) :e157874.|JCI Insight. 2024 Jun 25:e175416.|Mar Life Sci Technol. 2025 May 12.|Mol Carcinog. 2020 Oct;59 (10) :1147-1158.|Mol Cell Biochem. 2020 Sep;472 (1-2) :209-218.|Mol Cell Biochem. 2025 Feb;480 (2) :1183-1195.|Mol Cell Endocrinol. 2023 May 1:566-567:111891.|Mol Cell. 2025 Feb 20;85 (4) :843-856.e6.|Mol Hum Reprod. 2021 May 29;27 (6) :gaab032.|Mol Immunol. 2024 Sep 11:175:1-9.|Mol Med Rep. 2020 Aug;22 (2) :651-660.|Mol Reprod Dev. 2022 May;89 (5-6) :256-268.|Molecules. 2023 Dec 20, 29 (1), 50.|Mycopathologia. 2021 Jun;186 (3) :341-354.|Nat Commun. 2024 Apr 11;15 (1) :3165.|Nat Commun. 2025 Feb 17;16 (1) :1715.|Nat Immunol. 2025 Oct;26 (10) :1673-1685.|Nat Methods. 2023 Dec;20 (12) :2021-2033.|Nat Struct Mol Biol. 2025 May;32 (5) :853-863.|Neural Regen Res. 2023 Oct;18 (10) :2219-2228.|Neuron. 2025 Nov 18:S0896-6273 (25) 00803-7.|Neuropharmacology. 2021 Jun 15:191:108584.|New Phytol. 2024 Feb;241 (4) :1794-1812.|Oncogene. 2021 Apr;40 (14) :2581-2595.|Oncogene. 2022 Feb;41 (6) :907-919.|Oncol Lett. 2021 Nov;22 (5) :754.|Orthop Surg. 2021 Jun;13 (4) :1398-1407.|Oxid Med Cell Longev. 2022 Mar 10:2022:1863098.|PeerJ. 2023 Aug 23:11:e15890.|Peptides. 2022 Aug:154:170824.|Pharmacol Res. 2022 Sep 28;185:106473.|PLoS Negl Trop Dis. 2020 Aug 31;14 (8) :e0008660.|PLoS One. 2024 Aug 19;19 (8) :e0308977.|PLoS Pathog. 2025 Oct 27;21 (10) :e1013623.|Poult Sci|R Soc Open Sci. 2020 Jul 8;7 (7) :200635.|Redox Biol. 2024 Nov 5:78:103419.|Research Square Preprint. 2021 Apr.|Research Square Preprint. 2021 Feb.|Research Square Preprint. 2021 Nov.|Research Square Preprint. 2023 May 31.|Research Square Preprint. 2024 Apr 19.|Respir Res. 2021 Aug 3;22 (1) :216.|Respir Res. 2023 Sep 6;24 (1) :216.|Sci Rep. 2023 Aug 7;13 (1) :12809.|Sci Rep. 2025 Aug 7;15 (1) :28871.|Sci Total Environ. 2023 Dec 10:903:166449.|SSRN. 2023 Sep 18.|Stem Cell Rev Rep. 2024 Aug;20 (6) :1618-1635.|Stem Cells Int. 2022 Mar 21;2022:3742678.|Stem Cells Int. 2025 Sep 21:2025:8825935.|Theranostics. 2021 Jan 19;11 (7) :3392-3416.|Toxicology. 2024 Aug 6:153906.|Toxics. 2024 Mar 23;12 (4) :235.|Toxins. 2021 Jun 13;13 (6) :422.|Vet Microbiol. 2025 Sep 11:310:110726.|Vet Res. 2021 Oct 21;52 (1) :135.|Vet Res. 2024 Jul 29;55 (1) :93.|ACS Chem Neurosci. 2015 Jan 21;6 (1) :130-7. |ACS Infect Dis. 2023 Jul 14;9 (7) :1424-1436.|Acta Biochim Biophys Sin (Shanghai) . 2019 Apr 1;51 (4) :365-374.|Acta Pharmacol Sin. 2019 Oct;40 (10) :1314-1321.|Acta Pharmacol Sin. 2021 Jul;42 (7) :1090-1100.|Adv Exp Med Biol. 2022:1370:351-367.|Adv Sci (Weinh) . 2022 Aug;9 (23) :e2200559.|Adv Sci (Weinh) . 2024 Jul 2:e2402107.|Aging Cell. 2018 Jun;17 (3) :e12754. |Am J Physiol Heart Circ Physiol. 2018 Mar 1;314 (3) :H580-H592.|Am J Physiol Renal Physiol. 2019 Apr 1;316 (4) :F660-F673. |Am J Respir Cell Mol Biol. 2023 Mar;68 (3) :256-266.|Am J Transl Res. 2021 Nov 15;13 (11) :12536-12548.|Ann Transl Med. 2019 Dec;7 (23) :758.|Antioxid Redox Signal. 2023 Oct;39 (10-12) :777-793.|Antiviral Res. 2023 Jul:215:105635.|Aquaculture. 2025 Sep 15.|Arch Biochem Biophys. 2021 Nov 15:712:109044.|Arch Toxicol. 2022 Jul;96 (7) :2113-2122.|Arch Toxicol. 2022 Nov;96 (11) :2913-2926.|Atherosclerosis. 2019 Apr:283:92-99.|Biochem Biophys Res Commun. 2022 Nov 12:629:183-188.|Biochem Biophys Res Commun. 2019 Mar 5;510 (2) :219-223. |Biochim Biophys Acta Gen Subj. 2021 Mar;1865 (3) :129836.|Bioengineered. 2022 Apr;13 (4) :8747-8758.|Biomaterials. 2018 Sep;178:95-108.|Biomed Pharmacother. 2018 Apr:100:417-425.|Biomed Pharmacother. 2018 Dec:108:1294-1302.|Biomed Pharmacother. 2021 Jan;133:111023.|Biomed Res Int. 2022 Oct 25:2022:6006981.|Biomedicines. 2023 Jun 26;11 (7) :1833.|bioRxiv. 2019 Aug.|bioRxiv. 2023 Aug 14.|bioRxiv. 2024 May 2.|bioRxiv. 2025 May 05.|bioRxiv. 2025 Nov 20.|bioRxiv. January 18, 2022.|Blood Sci. 2024 Jul 10;6 (3) :e00192.|Blood. 2018 Jul 12;132 (2) :210-222. |BMC Complement Med Ther. 2022 Apr 6;22 (1) :100.|Br J Haematol. 2019 Jun;185 (5) :836-851.|Brain Behav Immun. 2019 Aug:80:711-724.|Cancer Lett. 2017 May 1:393:22-32.|Cancer Lett. 2018 Aug 28:430:201-214.|Cancer Manag Res. 2019 May 1:11:3887-3898.|Cancer Res. 2019 Sep 1;79 (17) :4466-4479. |Cancers (Basel) . 2022 May 9;14 (9) :2338.|Carbohyd Polym. 2019 Mar 1;207:371-381.|Cell Biochem Funct. 2021 Oct;39 (7) :908-920.|Cell Biol Int. 2020 Jan;44 (1) :89-97.|Cell Chem Biol. 2022 Jul 21;29 (7) :1113-1125.e6.|Cell Cycle. 2017 Apr 3;16 (7) :714-722.|Cell Death Dis. 2018 Feb 15;9 (3) :269. |Cell Death Dis. 2018 Oct 3;9 (10) :1015. |Cell Death Dis. 2024 Nov 13;15 (11) :821.|Cell Death Dis. 2018 Dec 5;9 (12) :1170.|Cell Death Dis. 2019 Jul 11;10 (7) :530.|Cell Immunol. 2022 Feb:372:104475.|Cell Immunol. 2024 Nov-Dec:405-406:104884.|Cell Physiol Biochem. 2018;50 (4) :1522-1534.|Cell Prolif. 2021 Mar;54 (3) :e12997.|Cell Prolif. 2022 May;55 (5) :e13221.|Cell Rep. 2022 Mar 15;38 (11) :110520.|Cell Rep. 2022 Mar 8;38 (10) :110486.|Cell Res. 2018 Dec;28 (12) :1171-1185. |Cell Signal. 2016 Feb;28 (2) :81-93.|Cell Signal. 2017 Apr:32:48-58.|Cell Signal. 2020 Mar;67:109522.|Cell Signal. 2022 Nov:99:110402.|Cell Transplant. 2020 Jan-Dec:29:963689720960190.|Chem Biol Interact. 2021 Oct 1:348:109634.|Chem Biol Interact. 2022 Oct 1:366:110125.|Chin Herb Med. 2022 Sep 1;14 (4) :554-562.|Clin Exp Pharmacol Physiol. 2019 Sep;46 (9) :861-871.|Clin Exp Pharmacol Physiol. 2022 Dec;49 (12) :1281-1293.|Clin Transl Med. 2020 Oct;10 (6) :e208.|CNS Neurosci Ther. 2020 Jan;26 (1) :101-116.|Cytokine. 2022 Nov:159:156013.|Dev Biol. 2018 Jan 15;433 (2) :404-415.|Dev Comp Immunol. 2020 Apr;105:103602.|DNA Cell Biol. 2021 Nov;40 (11) :1445-1455.|Drug Des Devel Ther. 2022 Apr 13;16:1107-1120.|Ecotoxicol Environ Saf. 2019 Nov 15:183:109508.|EMBO J. 2020 Feb 3;39 (3) :e102374. |EMBO J. 2022 Mar 1;41 (5) :e109386.|Environ Sci Pollut Res Int. 2018 Jun;25 (17) :16434-16445.|Environ Sci-Nano. 6 (8), May 2019.|Eur J Cancer. 2022 May 19;170:91-102.|Eur J Pharm Sci. 2018 Aug 30:121:243-250.|Eur J Pharmacol. 2023 Aug 5:952:175805.|Evid Based Complement Alternat Med. 2022 Jul 13:2022:7008907.|Exp Biol Med. 2020 Mar;245 (6) :562-575.|Exp Cell Res. 2019 Sep 1;382 (1) :111467.|Exp Cell Res. 2020 Jun 1;391 (1) :111886.|Exp Cell Res. 2022 Jun 15;415 (2) :113138.|Exp Mol Med. 2021 Apr;53 (4) :572-590.|Exp Physiol. 2021 Feb;106 (2) :438-449.|Exp Ther Med. 2023 Mar 14;25 (4) :188.|FASEB J. 2019 Aug;33 (8) :9565-9576.|FASEB J. 2019 Feb;33 (2) :2435-2450. |FEBS Lett. 2021 Nov;595 (21) :2665-2674.|Fish Shellfish Immunol. 2022 Oct:129:22-29.|Food Chem Toxicol. 2021 Dec:158:112592.|Food Chem Toxicol. 2021 Feb:148:111925.|Food Chem Toxicol. 2021 Feb:148:111926.|Food Chem X. 2022 Apr 30;14:100321.|Food Chem X. 2022 Jan 15:13:100211.|Food Sci Hum Wellness. 2025.|Food Sci Nutr. 2022 Jan 18;10 (2) :564-576.|Free Radic Biol Med. 2017 Nov:112:49-59.|Front Immunol. 2017 Oct 10:8:1278.|Front Immunol. 2018 Dec 7:9:2854.|Front Immunol. 2018 Jun 5:9:1225.|Front Immunol. 2022 Feb 3;13:746890.|Front Microbiol. 2020 Feb 28;11:320.|Front Microbiol. 2022 Jun 30;13:894356.|Front Mol Biosci. 2021 Jul 8:8:698975.|Front Mol Neurosci. 2017 Mar 13;10:51.|Front Pharmacol. 2021 Jan 11:11:531117.|Front Physiol. 2019 Jun 20;10:798.|Gene. 2019 Dec 24:144299. |Genome Biol. 2023 Feb 1;24 (1) :20.|Haematologica. 2020 Jan;105 (1) :124-135. |Heliyon. 2024 Jan 25;10 (3) :e24865.|Int Immunopharmacol. 2020 Jun;83:106473.|Int Immunopharmacol. 2021 Dec;101 (Pt A) :108264.|Int Immunopharmacol. 2022 Jun:107:108691.|Int Immunopharmacol. 2023 Apr:117:109890.|Int Immunopharmacol. 2024 Dec 9:145:113781.|Int Immunopharmacol. 2024 Jan 25:127:111372.|Int J Biochem Cell Biol. 2020 Apr;121:105703.|Int J Cancer. 2021 Apr 1;148 (7) :1743-1755.|Int J Clin Exp Pathol. 2017;10 (7) :7466-7474|Int J Mol Med. 2017 Jul;40 (1) :164-174.|J Adv Res. 2019 Feb 28:18:137-145.|J Agric Food Chem. 2021 Nov 3;69 (43) :12862-12869.|J Anim Sci Biotechnol. 2021 Feb 2;12 (1) :4.|J Appl Toxicol. 2020 Apr;40 (4) :470-482.|J Biomed Sci. 2025 Jan 6;32 (1) :5.|J Cachexia Sarcopenia Muscle. 2025 Aug;16 (4) :e70004.|J Cell Biochem. 2019 Feb;120 (2) :1979-1989.|J Cell Biochem. 2019 Jan;120 (1) :321-331. |J Cell Biochem. 2019 Oct;120 (10) :17872-17886. |J Cell Mol Med. 2020 May;24 (10) :5605-5614.|J Cell Mol Med. 2024 Apr;28 (8) :1-11.|J Cell Mol Med. 2024 Feb;28 (4) :e18143.|J Dairy Sci. 2025 Mar;108 (3) :2152-2168.|J Dent Res. 2019 Nov;98 (12) :1386-1396.|J Ethnopharmacol. 2024 Apr 25:330:118226.|J Eur Acad Dermatol Venereol. 2020 Apr;34 (4) :862-872.|J Exp Clin Cancer Res. 2021 Feb 1;40 (1) :53.|J Extracell Vesicles. 2025 Oct;14 (10) :e70165.|J Funct Foods. 2018 Jul;46:175-184.|J Funct Foods. 2025 Apr.|J Immunol Res. 2020 Feb 10;2020:6457879.|J Immunol Res. 2020 Jun 19;2020:4598476.|J Inflamm Res. 2021 Mar 23;14:1007-1017.|J Inorg Biochem. 2022 Apr 20;233:111838.|J Inorg Biochem. 2022 Apr:229:111725.|J Interferon Cytokine Res. 2019 Apr;39 (4) :224-232. |J Invest Dermatol. 2019 Dec;139 (12) :2488-2496.e4.|J Invest Dermatol. 2021 Apr;141 (4) :852-862.e6.|J Mater Sci Mater Med. 2019 Jul 19;30 (8) :87.|J Mol Cell Cardiol. 2015 Dec;89 (Pt B) :268-79. |J Mol Neurosci. 2019 May;68 (1) :111-119.|J Neuroinflammation. 2018 Jun 15;15 (1) :184.|J Neuroinflammation. 2020 Oct 28;17 (1) :321.|J Neuroinflammation. 2024 Aug 2;21 (1) :192.|J Neuroinflammation. 2018 Oct 19;15 (1) :291.|J Neurol Sci. 2020 Mar 15;410:116679.|J Periodontal Res. 2022 Jan;57 (1) :195-204.|J Periodontol. 2019 Sep;90 (9) :1002-1013.|J Periodontol. 2020 Aug;91 (8) :1085-1097.|J Periodontol. 2022 Mar;93 (3) :e60-e72.|J Pharmacol Exp Ther. 2022 Nov;383 (2) :172-181.|J Proteome Res. 2023 Apr 7;22 (4) :1080-1091.|J Reprod Dev. 2024 Aug 7;70 (4) :238-246.|J Steroid Biochem Mol Biol. 2021 Nov:214:106001.|J Therm Biol. 2025 Jan 28:127:104065.|J Transl Med. 2025 Feb 28;23 (1) :244.|JCI Insight. 2025 Nov 25:e196605.|Lab Invest. 2020 Aug;100 (8) :1042-1056.|Lab Invest. 2021 Oct;101 (10) :1353-1362.|Lab Invest. 2022 Aug;102 (8) :794-804.|Life Sci Alliance. 2022 Jun 2;5 (10) :e202101330.|Life Sci. 2019 Aug 15:231:116554.|Life Sci. 2020 Dec 1;262:118478.|Life Sci. 2022 Oct 1:306:120804.|Med Sci Monit. 2020 Aug 30;26:e923610.|Mediators Inflamm. 2020 Nov 3;2020:8925973. |Mol Cancer Res. 2019 Jun;17 (6) :1378-1390.|Mol Immunol. 2021 Mar:131:97-111.|Mol Med Rep. 2018 Jun;17 (6) :7595-7602. |Mol Med Rep. 2020 Nov;22 (5) :3667-3676.|Mol Med Rep. 2021 Dec;24 (6) :853.|Mol Omics. 2023 Aug 14;19 (7) :552-559.|Molecules. 2022 Feb 27;27 (5) :1577.|Nat Commun. 2025 Mar 15;16 (1) :2565.|Nat Immunol. 2018 Mar;19 (3) :233-245.|Neural Regen Res. 2021 Aug;16 (8) :1582-1591.|NPJ Biofilms Microbiomes. 2024 Jan 20;10 (1) :5.|Obes Facts. 2020;13 (1) :86-101.|Onco Targets Ther. 2020 Jun 23;13:5979-5991. |Onco Targets Ther. 2021 Jan 8:13:13437-13450.|Oncol Lett. 2019 Nov;18 (5) :5621-5627.|Oncol Rep. 2020 Jun;43 (6) :1964-1974.|Oncol Rep. 2022 Jan;47 (1) :11.|Oncotarget. 2017 May 16;8 (20) :33807-33826.|Oncotarget. 2017 May 30;8 (47) :82027-82036.|Oxid Med Cell Longev. 2017:2017:6175841.|Oxid Med Cell Longev. 2017:2017:7426458.|Peptides. 2016 Dec:86:72-79.|Pharmaceuticals (Basel) . 2022 Jun 17;15 (6) :758.|Pharmacol Res. 2018 Jul:133:218-235.|Phytomedicine. 2018 Mar 15:42:152-163.|Phytomedicine. 2021 Nov:92:153740.|Phytopathology. 2018 Jun;108 (6) :711-720. |Placenta. 2022 Apr:121:61-69.|PLoS One. 2020 Sep 3;15 (9) :e0235824.|Programa de Doctorado en Biomedicina. 2020 Sep.|Prostate. 2020 Oct;80 (14) :1203-1215.|Reprod Biol Endocrinol. 2018 May 31;16 (1) :55.|Res Sq. 2025 Jul 27.|Research Square Preprint. 2020 Nov.|Research Square Preprint. 2021 Oct.|Research Square Preprint. 2021 Sep.|Research Square Preprint. 2022 Feb.|Research Square Preprint. 2022 Jan.|Research Square Preprint. 2023 Nov 20.|Research Square Print. 2022 Jul.|Respir Res. 2022 Jan 11;23 (1) :6.|Respir Res. 2019 Jun 14;20 (1) :121.|Sci Rep. 2015 Oct 27;5:15535.|Sci Rep. 2019 Mar 5;9 (1) :3462.|Sci Rep. 2023 Feb 2;13 (1) :1894.|Science. 2022 Jul 8;377 (6602) :eabg9302.|Signal Transduct Target Ther. 2020 Aug 26;5 (1) :153.|SSRN. 2023 Jun 29.|Stem Cell Res Ther. 2020 Dec 14;11 (1) :541.|Stem Cell Res Ther. 2021 May 20;12 (1) :295.|Stem Cell Rev Rep. 2020 Dec;16 (6) :1280-1291.|Ther Adv Med Oncol. 2019 May 14:11:1758835919846806.|Theranostics. 2022 Oct 3;12 (16) :7051-7066.|Theriogenology. 2020 Nov;157:449-457.|Toxicol Appl Pharmacol. 2019 Mar 1:366:83-95.|Toxicol Appl Pharmacol. 2025 Jan 18:117232.|Toxicol Res (Camb) . 2021 Aug 31;10 (5) :1034-1044.|University of Pittsburgh. 2025.|Vaccines. 2019 Dec 14;7 (4) :216.|Vet Microbiol. 2022 Aug:271:109488.|Vet Parasitol. 2025 Apr 15:337:110471.|Viruses. 2022 Jul 2;14 (7) :1465.

• CAS Number:

  [109511-58-2]