JNJ 28610244

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Description

JNJ 28610244 is a H4R agonist, with a pKi of 7.3 and pEC50 of 7.0, respectively[1].

CAS Number

1251462-28-8

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jnj-28610244.html

Smiles

CN1CCC(/C(C(N2)=CC3=C2C=CC(C)=C3)=N/O)CC1

Molecular Formula

C16H21N3O

Molecular Weight

271.36

References & Citations

[1]Karim Dib, et al. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol. 2014 Sep;96 (3) :411-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

CID 136141537

CAS Number	1251462-28-8
PubChem CID	136141537
IUPAC Name	(NZ)-N-[(5-methyl-1H-indol-2-yl)-(1-methylpiperidin-4-yl)methylidene]hydroxylamine
Molecular Formula	C16H21N3O
Molecular Weight	271.36
XLogP	3.2
Topological Polar Surface Area	51.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	20
Formal Charge	0
Complexity	363

SMILES

CC1=CC2=C(C=C1)NC(=C2)/C(=N\O)/C3CCN(CC3)C

InChI

InChI=1S/C16H21N3O/c1-11-3-4-14-13(9-11)10-15(17-14)16(18-20)12-5-7-19(2)8-6-12/h3-4,9-10,12,17,20H,5-8H2,1-2H3/b18-16-

InChIKey

VOIJIMTXMUBFDD-VLGSPTGOSA-N

Chemical Structure

2D Structure

CAS: 1251462-28-8

CID: 136141537

Formula: C16H21N3O

MW: 271.36

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	271.36
XLogP3	3.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	271.168462302
Monoisotopic Mass	271.168462302
Topological Polar Surface Area	51.6 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	363
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
T24207-01	JNJ-28610244

JNJ 28610244

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